Trinity is Ireland's leading university and is ranked 87th in the world (QS World University Rankings 2025).
Founded in 1592, the University is steeped in history with a reputation for excellence in education, research, and innovation, which has been inspiring generations of thinkers for over 400 years.
Applications are invited for a motivated and self-driven postdoctoral researcher to join The O'Boyle Group based in The Department of Microbiology, School of Genetics and Microbiology, Trinity College Dublin.
The project will involve the development and in vitro testing of therapeutics against Crohn's disease-associated Enterobacteriaceae.
Inflammatory bowel disease (IBD) comprises distinct clinical subtypes, with unique microbial associations, pathological features and responses to treatment.
Ileal Crohn's disease (ICD) has the strongest association with over-proliferation of a specific family of bacteria, the Enterobacteriaceae.
While their role in disease progression is poorly understood, they are considered an attractive target for therapies aimed at dampening IBD-associated inflammation.
This project will involve the isolation and characterisation of opportunistic Enterobacteriaceae from intestinal biopsies, development of patient-derived organoids, metabolomics, metagenomics, advanced microscopy, dietary analysis, and classic microbiology.
The project will be further supported by Public and Patient Involvement (PPI) whereby a team comprising inflammatory bowel disease patients and their family members will co-design elements of the research.
Application Procedure