Role Summary:
My client is a really interesting biotech looking for a Principal Scientist to join and take on responsibility for leading preclinical development activities from discovery to IND-enabling studies. Day-to-day, you’ll provide hands-on technical leadership, mentor junior scientists, and ensure the successful translation of novel therapeutic candidates toward the clinic. You will be the kind of scientist that has a broad understanding of the pre-clinical, drug discovery up to translational processes, a strong communicator, collaborator and confident contributor both in the lab and operational perspective.
Key Responsibilities:
* Lead end-to-end preclinical development, from lead identification and optimisation through IND-enabling studies.
* Design and oversee experimental plans to advance complex biologics or gene-modified products.
* Support translational research strategies and regulatory documentation preparation.
* Mentor and develop junior scientists, sharing best practices and industry standards.
* Collaborate with cross-functional teams to meet project milestones and budgets.
* Stay current on emerging trends in advanced therapies, biologics, and regulatory expectations.
Essential Experience & Skills:
* 5–7+ years in industry as a Principal Scientist or equivalent role in biotech/pharma.
* Proven track record advancing complex biologics or gene-modified therapies through IND-enabling studies.
* Demonstrated expertise in optimising lead candidates for preclinical development.
* Comprehensive understanding of the full preclinical development lifecycle.
* Strong mentoring and interpersonal skills, with experience developing junior scientists.
* Comfort working in a biotech environment with dynamic timelines and budgets.
Desirable Experience:
* Exposure to advanced therapeutic modalities such as cell therapy, regenerative medicine, or novel delivery systems.
* Familiarity with oncology indications or other high-value clinical targets.
Additional Details:
* Competitive salary depending on experience.
* Future equity or bonus incentives planned as the company continues to grow.
* Flexible, collaborative environment suited to biotech professionals looking for impact and ownership.
If you're the kind of candidate that is looking to help drive cutting-edge therapeutics toward the clinic, I'd love to understand more about your career aspirations and how this role could fit in with your next step!
I am expecting this role to be heavily over subscribed. Due to time constraints I am not always able to respond to every applicant but regardless I wish you the best with your search and will always endeavour to speak to as many relevant candidates as possible!
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