Applications are invited for a temporary post of a UCD Post-doctoral Research Fellow Level 1 within UCD School of Medicine. This post is funded by a Research Ireland Frontiers for the Future Award to Associate Professor Rory Johnson. The RIBOncology project aims to discover and characterise cancer-promoting mutations in long noncoding RNA (lncRNA) genes by analysing whole genome sequences from over 13,000 tumours provided by Genomics England. The project spans computational driver gene discovery, high-throughput functional screening, mechanistic prediction of driver mutations, and preclinical therapeutic validation using antisense oligonucleotides. The Postdoctoral Researcher (Experimental) will lead the biological validation and therapeutic development aspects of the project. The post holder will perform high-throughput CRISPR functional screens to evaluate the disease-modifying activity of predicted driver lncRNAs across cancer cell models, develop new experimental approaches to study the functional impact of tumour mutations, and generate preclinical proof of concept for therapeutic targeting of driver lncRNAs using antisense oligonucleotides. In vivo validation will be conducted in collaboration with a partner group at RCSI. This post reports directly to Associate Professor Rory Johnson. The post holder will be expected to co-supervise graduate students, contribute to peer-reviewed publications, and engage in the wider research activities of the GOLD Lab, the Conway Institute, and the School of Medicine. Fixed Salary: €46,805 Per Annum Closing date: 12:00 noon (local Irish time) on 21 May 2026. Applications must be submitted by the closing date and time specified. Any applications which are still in progress at the closing time of 12:00 noon (Local Irish Time) on the specified closing date will be cancelled automatically by the system. UCD are unable to accept late applications. UCD do not require assistance from Recruitment Agencies. Any CVs submitted by Recruitment Agencies will be returned. The PD1 position is intended for early-stage researchers, either just after completion of a PhD or for someone entering a new area for the first time. If you have already completed your PD1 stage in UCD or will soon complete a PD1, or you are an external applicant whose total Postdoctoral experience, inclusive of the duration of the advertised post, would exceed 4 years, you should not apply and should refer to PD2 posts instead. To be considered for this role you will be redirected to and must complete the application process on our careers page. To start the process click the Apply button below to Login/Register.