Are you an experienced scientific leader looking to shape the future of respiratory and genetic medicine? We are seeking aPrincipal Scientistto drive innovative discovery and preclinical research programmes within a growing biotech environment. This is an exceptional opportunity to lead impactful scientific initiatives, guide talented researchers, and contribute directly to the development of next-generation therapies.About the RoleAs Principal Scientist, you will lead cross-disciplinary research efforts spanning molecular biology, RNA therapeutics, extracellular vesicles, and gene-based approaches. You will oversee complex in vitro and in vivo studies, guide strategic scientific decisions, and support progression of new therapeutic concepts toward clinical development.This role is ideal for a scientist with deep technical expertise, strong leadership skills, and a passion for translating cutting-edge biology into meaningful patient outcomes.Key ResponsibilitiesLead advanced discovery and preclinical research projects in respiratory or RNA-based therapeutic development.Design, execute, and oversee a wide range of experimental programmes, including molecular assays, cellular models, and animal studies to evaluate efficacy, safety, and biodistribution.Collaborate closely with teams across Process Development, Analytical Sciences, Translational Biology, and Regulatory Affairs.Mentor and develop junior scientists and research associates, fostering a high-performance, innovation-driven culture.Analyse, interpret, and present scientific data to internal stakeholders and at external scientific conferences or publications.Contribute to scientific strategy, target evaluation, and platform-level innovation.Support preparation of technical documentation for regulatory filings and grant applications.Qualifications & ExperiencePhD in Molecular Biology, Biochemistry, Pharmacology, or a related life science discipline.Minimum 8 years of R&D experience within biotechnology or pharmaceutical environments.Proven track record of leading research projects and delivering results within fast-paced settings.Expertise in extracellular vesicle biology, RNA or protein cargo design, gene-based therapeutics, or pulmonary/inhalation delivery is highly desirable.Strong communication, data interpretation, cross-functional collaboration, and scientific mentorship skills.