Location: Monksland, Athlone
37.5 per week (Mon–Fri, 09:00–17:00, flexible)
Competitive Salary And Benefits
Opening date: 14/04/2026
Closing date: midnight 20/04/2026
The Senior OT Infrastructure Engineer is a key member of the AAMF Manufacturing Systems team, responsible for the design, reliability, cybersecurity and lifecycle management of GMP‑critical OT infrastructure. This includes DCS/PLC/SCADA systems, data historians, servers and networks that underpin drug product manufacturing.
Working at the interface of IT and Automation, the role ensures systems remain highly available, secure and compliant, while enabling digitalisation, analytics and AI initiatives aligned with Industry 4.0 and site strategy.
Accountabilities
Own reliability, availability and performance of GMP‑critical OT systems and networks
Maintain OT systems in a validated, audit‑ready state (cGMP, GAMP, 21 CFR Part 11, data integrity)
Plan and implement patching, upgrades, preventative maintenance and obsolescence strategies
Lead OT cybersecurity controls including network segmentation, vulnerability management and incident response
Govern change control, risk assessments, IQ/OQ/PQ support, and deviation investigations
Manage backups, disaster recovery, redundancy and restore testing
Drive OT upgrade projects from design through validation and cutover
Manage third‑party vendors and system integrators
Support AVEVA PI data ingestion, data quality and infrastructure readiness for analytics and AI solutions
Collaborate with Automation, Manufacturing, QA, Global Security and IT
Support training, standardisation and OT maturity across the manufacturing network
Essential Skills & Experience
Proven experience in OT / industrial IT within GMP manufacturing environments
Hands‑on experience with DCS/PLC/SCADA systems (DeltaV strongly preferred)
Strong experience with AVEVA / OSIsoft PI and SQL Server in validated environments
Expertise in OT infrastructure (VMware/Hyper‑V, Windows Server, backups, endpoint hardening)
Industrial networking and protocols (VLANs, firewalls, OPC/OPC UA, Industrial Ethernet)
OT cybersecurity implementation and vulnerability management
Strong knowledge of cGMP, GAMP 5, change control and validation
Proven ability to lead complex OT projects and manage vendors
Excellent communication and technical leadership skills
Desirable Skills & Experience
Degree in Engineering, Computer Science or similar
Experience with Siemens, Rockwell, BMS/HVAC, Kepware or AVEVA platforms
Scripting (PowerShell) and cloud/analytics integration exposure
OT/IT certifications (ISA/IEC 62443, GICSP, VMware, Microsoft)
At AstraZeneca’s Alexion Rare Disease unit, work connects directly to people living with rare and devastating conditions, turning advanced science into meaningful impact every day. Colleagues collaborate in an open, inclusive environment that blends the agility of a biotech with the reach and resources of a global biopharma, enabling bold ideas in digitalisation, AI and advanced manufacturing to move quickly from concept to reality. Learning is continuous, with opportunities to grow skills, broaden experience and contribute to pioneering therapies that address areas of high unmet need while staying grounded in integrity, transparency and ethical decision‑making.
If this opportunity resonates, apply now to help shape the future of manufacturing for people living with rare diseases!
Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.
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