Organisation/Company Dublin City University Department School of Biotechnology Research Field Biological sciences » Biology Researcher Profile First Stage Researcher (R1) Positions Postdoc Positions Country Ireland Application Deadline 6 Jan *********:29 (Europe/London) Type of Contract Temporary Job Status Full-time Hours Per Week 40 Offer Starting Date 26 Jan **** Is the job funded through the EU Research Framework Programme?
Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
Project Background
Colorectal (colon) cancer is among the leading causes of cancer-related deaths globally.
Early diagnosis is critical for improving patient outcomes, yet current screening methods are often invasive, costly, and lack sensitivity.
This Enterprise Ireland–funded project aims to develop a novel, protein-based diagnostic test for colon cancer, leveraging molecular biology, recombinant protein production, and immunoassay development.
The project will be based in the School of Biotechnology at DCU and will involve close collaboration with academic partners at Trinity College Dublin (TCD).
The successful candidate will contribute to the design, production, and validation of recombinant antibodies and the development of prototype diagnostic assays.
Role Profile
The Postdoctoral Researcher will join a multidisciplinary research team focused on translating molecular and immunological discoveries into diagnostic technologies.
The postholder will be responsible for:
Molecular cloning and construct design for recombinant protein expression in E. coli
Expression and purification of recombinant and fusion proteins
Biochemical and biophysical characterisation of recombinant proteins
Development and optimisation of ELISA or related immunoassays for biomarker detectionDocumentation and reporting of experimental data in accordance with project and funding requirements
Liaising and coordinating research activities with collaborators at Trinity College Dublin
Preparation of manuscripts, progress reports, and dissemination materials
Qualifications and Experience
PhD in Molecular Biology, Biochemistry, Immunology, or a closely related discipline.
Strong hands-on experience in molecular cloning, gene expression in E. coli, and recombinant protein purification.
Demonstrated proficiency in standard molecular and protein analysis techniques (e.g., SDS-PAGE, Western blotting, spectrophotometry).
Excellent problem-solving, organisational, and interpersonal skills.
Proven ability to work independently and collaboratively within a multidisciplinary team.
Experience in fusion protein design and expression in E. coli.
Expertise in antibody engineering or recombinant antibody fragment generation.
Experience in ELISA or other immunoassay development for diagnostic applications.
Background in translational biomedical research or diagnostic assay development.
Molecular cloning methods (restriction/ligation, Gibson Assembly)
PCR and quantitative PCR
Affinity chromatography (e.g., Ni-NTA, GST-tag purification)
Protein quantification and stability assessment
ELISA or related immunoassay optimisation
Salary Scale
The salary for this position will be aligned to the Postdoctoral Researcher salary scale commensurate with qualifications and experience.
Where to apply
E-mail ******
Requirements
Research Field Biological sciences » Biology Education Level PhD or equivalent
Languages ENGLISH Level Excellent
Research Field Biological sciences » Other Years of Research Experience 1 - 4
Additional Information
Work Location(s)
Number of offers available 1 Company/Institute Dublin City University Country Ireland State/Province State/Province Not Applicable City Dublin City University, Glasnevin Campus Postal Code Dublin 9 Street School of Biotechnology
Contact
State/Province State/Province Not Applicable City Dublin City University, Glasnevin Campus Website / Street School of Biotechnology Postal Code Dublin 9 E-Mail ****** Phone *********
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