Principal Scientist
Location: Ireland (on-site)
Reports to: C‑Suite
Summary
I'm working with an exciting biotech who are looking for their first Head of Translational to lead their scientific direction and hands‑on lab execution for novel cell & gene therapies. Your role will be to drive programs from discovery into preclinical development and IND/CTA enabling stages. Work cross functionally with internal teams and external partners to advance multiple therapeutic candidates. This is not just an opportunity to work at the cutting edge but the bleeding edge of science, my client is looking for strong scientific experience and extensive experience in team leadership, management and building with future growth potential around 20 headcount. They are open to EU wide and international candidates and willing to offer support to bring the right person into the team.
Responsibilities
You will own the scientific strategy and experimental leadership across discovery programs
Design and deliver preclinical studies focused on delivery, efficacy, safety, and MoA
Develop and validate molecular and cellular potency/identity assays
Lead cross‑functional project planning with CMC, translational and regulatory groups
Manage collaborations with CRO/academia/industry partners
Guide IP-relevant innovation and scientific documentation
Mentor R&D team members and promote lab excellence and compliance
Ensure data integrity, SOP adherence, equipment stewardship and safety standards
Required Experience
PhD in life sciences discipline (molecular/cell biology, gene therapy, immunology etc.)
5–7+ years post PhD experience in biotech or advanced biologics
Proven Translational ability to progress therapeutics through discovery to IND enabling work
Expertise in molecular & cellular engineering (RNA, gene delivery, transfection etc.)
Experience with advanced cell & gene therapies highly advantageous
Experience working with regulatory teams and frameworks
Hands‑on analytical assay design and interpretation (e.g., qPCR, flow, ELISA, Western)
Familiarity with upstream/downstream process development and scale‑up
Understanding of GLP/GMP alignment and documentation for regulatory submissions
Skilled in cross‑functional leadership and navigating fast‑moving biotech settings
Preferred
Respiratory or oncology models
Experience supporting IND/CTA or IMPD enabling studies
Personal Qualities
Hands on, proactive scientific leadership
Strong organization, analytical thinking, and attention to detail
Resilient, collaborative and motivated by translational impact
What’s Offered
Lead cutting edge programs in gene delivery and regenerative medicine
Visible role in a high growth biotech with major unmet need focus
Competitive salary and performance‑linked compensation
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